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Accidental Ketamine Overdose Caused Matthew Perry’s Death, Autopsy Reveals

Contributing factors in Mr. Perry’s death include drowning, coronary artery disease and the effects of buprenorphine (used to treat opioid use disorder),” the medical examiner said in a statement.
Actor Matthew Perry died as a result of "the acute effects of ketamine", the medical report said.

Matthew Perry, the iconic star of “Friends,” met an untimely end due to the “acute effects of ketamine,” as revealed by the recent toxicology report from the Los Angeles County medical examiner. The beloved actor, aged 54, was discovered unresponsive in the heated end of his pool on October 28, setting in motion a series of events that led to his accidental death.

The autopsy report, while ruling out foul play, cites the “acute effects of ketamine” as the primary cause, coupled with contributing factors such as “drowning, coronary artery disease, and buprenorphine effects.”

After playing pickleball in the morning and returning home, Perry’s aide discovered him dead after he had left for a short while. Even though the police declared him dead at 4:17 p.m.; in the early hours of October 29, his body was taken to the Forensic Science Center.

The actor, most known for his depiction of Chandler Bing, had a long history of addiction, but he had apparently been clean for 19 months before to his death. Perry had been receiving ketamine infusion therapy for depression and anxiety, with the most recent session taking place only a week and a half before his death.

Matthew Perry nearly missed out on 'Friends' role that changed his life

Witnesses attested to his positive response to treatment and cheerful demeanor during this time.

Ketamine, FDA-approved as an anesthetic since the 1970s, carries both potential benefits and risks. While research suggests its effectiveness in medically-supervised depression and anxiety treatment, the drug is also known for its dissociative effects and association with hallucinations, commonly seen in nightclub and party scenes. The toxicology report indicates trace amounts of ketamine in Perry’s stomach, but significantly elevated levels in his blood (3.54 micrograms per milliliter), leading investigators to conclude that his cause of death was not linked to prior infusion therapy.

Julia Roberts addresses 'heartbreaking' death of Friends star and  ex-boyfriend Matthew Perry | The Independent

Perry’s rise to stardom on “Friends” immortalized him as Chandler Bing, a character cherished for his eccentricities and unique personality. In his 2022 memoir, “Friends, Lovers and the Big Terrible Thing,” Perry candidly shared his struggles with addiction, emphasizing the importance of understanding it as a disease and urging those affected to seek help without self-blame. As fans mourn the loss of a beloved actor, the circumstances surrounding his tragic end shed light on the complexities of his personal journey.

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